Tudor-interacting repair regulator protein (NUDT16-like protein 1) (Protein syndesmos)
1_MSTAA 6_ VPELK 11_ QISRV 16_ EAMRL 21_ GPGWS 26_ HSCHA 31_ MLYAA 36_ NPGQL 41_ FGRIP 46_ MRFSV 51_ LMQMR 56_ FDGLL 61_ GFPGG 66_ FVDRR 71_ FWSLE 76_ DGLNR 81_ VLGLG 86_ LGCLR 91_ LTEAD 96_ YLSSH 101_ LTEGP 106_ HRVVA 111_ HLYAR 116_ QLTLE 121_ QLHAV 126_ EISAV 131_ HSRDH 136_ GLEVL 141_ GLVRV 146_ PLYTQ 151_ KDRVG 156_ GFPNF 161_ LSNAF 166_ VSTAK 171_ CQLLF 176_ ALKVL 181_ NMMPE 186_ EKLVE 191_ ALAAA 196_ TEKQK 201_ KALEK 206_LLPAS
1: Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299)