Matrix remodeling-associated protein 8 (Limitrin)
1_MALPS 6_ RILLW 11_ KLVLL 16_ QSSAV 21_ LLHSG 26_ SSVPA 31_ AAGSS 36_ VVSES 41_ AVSWE 46_ AGARA 51_ VLRCQ 56_ SPRMV 61_ WTQDR 66_ LHDRQ 71_ RVLHW 76_ DLRGP 81_ GGGPA 86_ RRLLD 91_ LYSAG 96_ EQRVY 101_ EARDR 106_ GRLEL 111_ SASAF 116_ DDGNF 121_ SLLIR 126_ AVEET 131_ DAGLY 136_ TCNLH 141_ HHYCH 146_ LYESL 151_ AVRLE 156_ VTDGP 161_ PATPA 166_ YWDGE 171_ KEVLA 176_ VARGA 181_ PALLT 186_ CVNRG 191_ HVWTD 196_ RHVEE 201_ AQQVV 206_ HWDRQ 211_ PPGVP 216_ HDRAD 221_ RLLDL 226_ YASGE 231_ RRAYG 236_ PLFLR 241_ DRVAV 246_ GADAF 251_ ERGDF 256_ SLRIE 261_ PLEVA 266_ DEGTY 271_ SCHLH 276_ HHYCG 281_ LHERR 286_ VFHLT 291_ VAEPH 296_ AEPPP 301_ RGSPG 306_ NGSSH 311_ SGAPG 316_ PDPTL 321_ ARGHN 326_ VINVI 331_ VPESR 336_ AHFFQ 341_ QLGYV 346_ LATLL 351_ LFILL 356_ LVTVL 361_ LAARR 366_ RRGGY 371_ EYSDQ 376_ KSGKS 381_ KGKDV 386_ NLAEF 391_ AVAAG 396_ DQMLY 401_ RSEDI 406_ QLDYK 411_ NNILK 416_ ERAEL 421_ AHSPL 426_ PAKYI 431_ DLDKG 436_FRKEN
1: Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:22492581, PubMed:23386276). Mediates heterophilic cell-cell interactions in vitro (By similarity). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity). Stimulates formation of primary cilia in chondrocytes (By similarity). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (By similarity). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (PubMed:23386276). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (PubMed:23386276). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (PubMed:23386276). May play a role in the maturation and maintenance of the blood-brain barrier (By similarity)
2: (Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses