Transcription factor Ovo-like 2 (hOvo2) (Zinc finger protein 339)
1_MPKVF 6_ LVKRR 11_ SLGVS 16_ VRSWD 21_ ELPDE 26_ KRADT 31_ YIPVG 36_ LGRLL 41_ HDPPE 46_ DCRSD 51_ GGSSS 56_ GSGSS 61_ SAGEP 66_ GGAES 71_ SSSPH 76_ APESE 81_ TPEPG 86_ DAEGP 91_ DGHLA 96_ TKQRP 101_ VARSK 106_ IKFTT 111_ GTCSD 116_ SVVHS 121_ CDLCG 126_ KGFRL 131_ QRMLN 136_ RHLKC 141_ HNQVK 146_ RHLCT 151_ FCGKG 156_ FNDTF 161_ DLKRH 166_ VRTHT 171_ GIRPY 176_ KCNVC 181_ NKAFT 186_ QRCSL 191_ ESHLK 196_ KIHGV 201_ QQQYA 206_ YKQRR 211_ DKLYV 216_ CEDCG 221_ YTGPT 226_ QEDLY 231_ LHVNS 236_ AHPGS 241_ SFLKK 246_ TSKKL 251_ AALLQ 256_ GKLTS 261_ AHQEN 266_TSLSE
1: Zinc-finger transcription repressor factor (PubMed:19700410). Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (PubMed:19700410). Important for the correct development of primordial germ cells in embryos (By similarity). Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Essential for brown/beige adipose tissue-mediated thermogenesis, is necessary for the development of brown adipocytes. In white adipose tissues, limits adipogenesis by blocking CEBPA binding to its transcriptional targets and inhibiting its transcription factor activity (By similarity)