Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog)
1_MEAAG 6_ SPAAT 11_ ETGKY 16_ IASTQ 21_ RPDGT 26_ WRKQR 31_ RVKEG 36_ YVPQE 41_ EVPVY 46_ ENKYV 51_ KFFKS 56_ KPELP 61_ PGLSP 66_ EATAP 71_ VTPSR 76_ PEGGE 81_ PGLSK 86_ TAKRN 91_ LKRKE 96_ KRRQQ 101_ QEKGE 106_ AEALS 111_ RTLDK 116_ VSLEE 121_ TAQLP 126_ SAPQG 131_ SRAAP 136_ TAASD 141_ QPDSA 146_ ATTEK 151_ AKKIK 156_ NLKKK 161_ LRQVE 166_ ELQQR 171_ IQAGE 176_ VSQPS 181_ KEQLE 186_ KLARR 191_ RALEE 196_ELEDL
1: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC