Ferroptosis suppressor protein 1 (FSP1) (EC 1.6.5.-) (Apoptosis-inducing factor homologous mitochondrion-associated inducer of death) (AMID) (p53-responsive gene 3 protein)
1_MGSQV 6_ SVESG 11_ ALHVV 16_ IVGGG 21_ FGGIA 26_ AASQL 31_ QALNV 36_ PFMLV 41_ DMKDS 46_ FHHNV 51_ AALRA 56_ SVETG 61_ FAKKT 66_ FISYS 71_ VTFKD 76_ NFRQG 81_ LVVGI 86_ DLKNQ 91_ MVLLQ 96_ GGEAL 101_ PFSHL 106_ ILATG 111_ STGPF 116_ PGKFN 121_ EVSSQ 126_ QAAIQ 131_ AYEDM 136_ VRQVQ 141_ RSRFI 146_ VVVGG 151_ GSAGV 156_ EMAAE 161_ IKTEY 166_ PEKEV 171_ TLIHS 176_ QVALA 181_ DKELL 186_ PSVRQ 191_ EVKEI 196_ LLRKG 201_ VQLLL 206_ SERVS 211_ NLEEL 216_ PLNEY 221_ REYIK 226_ VQTDK 231_ GTEVA 236_ TNLVI 241_ LCTGI 246_ KINSS 251_ AYRKA 256_ FESRL 261_ ASSGA 266_ LRVNE 271_ HLQVE 276_ GHSNV 281_ YAIGD 286_ CADVR 291_ TPKMA 296_ YLAGL 301_ HANIA 306_ VANIV 311_ NSVKQ 316_ RPLQA 321_ YKPGA 326_ LTFLL 331_ SMGRN 336_ DGVGQ 341_ ISGFY 346_ VGRLM 351_ VRLTK 356_ SRDLF 361_ VSTSW 366_KTMRQ
1: A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis (PubMed:31634899, PubMed:31634900, PubMed:35922516, PubMed:39881208). At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis (PubMed:31634899, PubMed:31634900). Acts in parallel to GPX4 to suppress phospholipid peroxidation and ferroptosis (PubMed:31634899, PubMed:31634900). This anti-ferroptotic function is independent of cellular glutathione levels (PubMed:31634899, PubMed:31634900). Also acts as a potent radical-trapping antioxidant by mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle: catalyzes NAD(P)H-dependent reduction of vitamin K (phylloquinone, menaquinone-4 and menadione) to hydroquinone forms (PubMed:35922516). Hydroquinones act as potent radical-trapping antioxidants inhibitor of phospholipid peroxidation and ferroptosis (PubMed:35922516). May play a role in mitochondrial stress signaling (PubMed:26689472). Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death (PubMed:26689472). Capable of DNA binding in a non-sequence specific way (PubMed:15958387)