Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.3.-) (RIO kinase 1)
1_MDYRR 6_ LLMSR 11_ VVPGQ 16_ FDDAD 21_ SSDSE 26_ NRDLK 31_ TVKEK 36_ DDILF 41_ EDLQD 46_ NVNEN 51_ GEGEI 56_ EDEEE 61_ EGYDD 66_ DDDDW 71_ DWDEG 76_ VGKLA 81_ KGYVW 86_ NGGSN 91_ PQANR 96_ QTSDS 101_ SSAKM 106_ STPAD 111_ KVLRK 116_ FENKI 121_ NLDKL 126_ NVTDS 131_ VINKV 136_ TEKSR 141_ QKEAD 146_ MYRIK 151_ DKADR 156_ ATVEQ 161_ VLDPR 166_ TRMIL 171_ FKMLT 176_ RGIIT 181_ EINGC 186_ ISTGK 191_ EANVY 196_ HASTA 201_ NGESR 206_ AIKIY 211_ KTSIL 216_ VFKDR 221_ DKYVS 226_ GEFRF 231_ RHGYC 236_ KGNPR 241_ KMVKT 246_ WAEKE 251_ MRNLI 256_ RLNTA 261_ EIPCP 266_ EPIML 271_ RSHVL 276_ VMSFI 281_ GKDDM 286_ PAPLL 291_ KNVQL 296_ SESKA 301_ RELYL 306_ QVIQY 311_ MRRMY 316_ QDARL 321_ VHADL 326_ SEFNM 331_ LYHGG 336_ GVYII 341_ DVSQS 346_ VEHDH 351_ PHALE 356_ FLRKD 361_ CANVN 366_ DFFMR 371_ HSVAV 376_ MTVRE 381_ LFEFV 386_ TDPSI 391_ THENM 396_ DAYLS 401_ KAMEI 406_ ASQRT 411_ KEERS 416_ SQDHV 421_ DEEVF 426_ KRAYI 431_ PRTLN 436_ EVKNY 441_ ERDMD 446_ IIMKL 451_ KEEDM 456_ AMNAQ 461_ QDNIL 466_ YQTVT 471_ GLKKD 476_ LSGVQ 481_ KVPAL 486_ LENQV 491_ EERTC 496_ SDSED 501_ IGSSE 506_ CSDTD 511_ SEEQG 516_ DHARP 521_ KKHTT 526_ DPDID 531_ KKERK 536_ KMVKE 541_ AQREK 546_ RKNKI 551_ PKHVK 556_ KRKEK 561_TAKTK
1: Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503)