DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed]
1_MTEEV 6_ DFLGQ 11_ DSDGG 16_ SEEVV 21_ LTPAE 26_ LIERL 31_ EQAWM 36_ NEKFA 41_ PELLE 46_ SKPEI 51_ VECVM 56_ EQLEH 61_ MEENL 66_ RRAKR 71_ EDLKV 76_ SIHQM 81_ EMERI 86_ RYVLS 91_ SYLRC 96_ RLMKI 101_ EKFFP 106_ HVLEK 111_ EKTRP 116_ EGEPS 121_ SLSPE 126_ ELAFA 131_ REFMA 136_ NTESY 141_ LKNVA 146_ LKHMP 151_ PNLQK 156_ VDLFR 161_ AVPKP 166_ DLDSY 171_ VFLRV 176_ RERQE 181_ NILVE 186_ PDTDE 191_ QRDYV 196_ IDLEK 201_ GSQHL 206_ IRYKT 211_ IAPLV 216_ASGAV
1: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232)