Transcription elongation factor A protein-like 7 (TCEA-like protein 7) (Transcription elongation factor S-II protein-like 7)
1_MQKPC 6_ KENEG 11_ KPKCS 16_ VPKRE 21_ EKRPY 26_ GEFER 31_ QQTEG 36_ NFRQR 41_ LLQSL 46_ EEFKE 51_ DIDYR 56_ HFKDE 61_ EMTRE 66_ GDEME 71_ RCLEE 76_ IRGLR 81_ KKFRA 86_ LHSNH 91_RHSRD
1: Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines