Suppressor of IKBKE 1 (Suppressor of IKK-epsilon)
1_MSCTI 6_ EKILT 11_ DAKTL 16_ LERLR 21_ EHDAA 26_ AESLV 31_ DQSAA 36_ LHRRV 41_ AAMRE 46_ AGTAL 51_ PDQYQ 56_ EDASD 61_ MKDMS 66_ KYKPH 71_ ILLSQ 76_ ENTQI 81_ RDLQQ 86_ ENREL 91_ WISLE 96_ EHQDA 101_ LELIM 106_ SKYRK 111_ QMLQL 116_ MVAKK 121_ AVDAE 126_ PVLKA 131_ HQSHS 136_ AEIES 141_ QIDRI 146_ CEMGE 151_ VMRKA 156_ VQVDD 161_ DQFCK 166_ IQEKL 171_ AQLEL 176_ ENKEL 181_ RELLS 186_ ISSES 191_ LQARK 196_ ENSMD 201_TASQA
1: Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways (PubMed:16281057). Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:30622739)