Protein pelota homolog (EC 3.1.-.-)
1_MKLVR 6_ KNIEK 11_ DNAGQ 16_ VTLVP 21_ EEPED 26_ MWHTY 31_ NLVQV 36_ GDSLR 41_ ASTIR 46_ KVQTE 51_ SSTGS 56_ VGSNR 61_ VRTTL 66_ TLCVE 71_ AIDFD 76_ SQACQ 81_ LRVKG 86_ TNIQE 91_ NEYVK 96_ MGAYH 101_ TIELE 106_ PNRQF 111_ TLAKK 116_ QWDSV 121_ VLERI 126_ EQACD 131_ PAWSA 136_ DVAAV 141_ VMQEG 146_ LAHIC 151_ LVTPS 156_ MTLTR 161_ AKVEV 166_ NIPRK 171_ RKGNC 176_ SQHDR 181_ ALERF 186_ YEQVV 191_ QAIQR 196_ HIHFD 201_ VVKCI 206_ LVASP 211_ GFVRE 216_ QFCDY 221_ LFQQA 226_ VKTDN 231_ KLLLE 236_ NRSKF 241_ LQVHA 246_ SSGHK 251_ YSLKE 256_ ALCDP 261_ TVASR 266_ LSDTK 271_ AAGEV 276_ KALDD 281_ FYKML 286_ QHEPD 291_ RAFYG 296_ LKQVE 301_ KANEA 306_ MAIDT 311_ LLISD 316_ ELFRH 321_ QDVAT 326_ RSRYV 331_ RLVDS 336_ VKENA 341_ GTVRI 346_ FSSLH 351_ VSGEQ 356_ LSQLT 361_ GVAAI 366_ LRFPV 371_ PELSD 376_QEGDS
1: Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27543824, PubMed:27863242). In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27543824, PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy (PubMed:29861391)