DNA replication complex GINS protein PSF3 (GINS complex subunit 3)
1_MSEAY 6_ FRVES 11_ GALGP 16_ EENFL 21_ SLDDI 26_ LMSHE 31_ KLPVR 36_ TETAM 41_ PRLGA 46_ FFLER 51_ SAGAE 56_ TDNAV 61_ PQGSK 66_ LELPL 71_ WLAKG 76_ LFDNK 81_ RRILS 86_ VELPK 91_ IYQEG 96_ WRTVF 101_ SADPN 106_ VVDLH 111_ KMGPH 116_ FYGFG 121_ SQLLH 126_ FDSPE 131_ NADIS 136_ QSLLQ 141_ TFIGR 146_ FRRIM 151_ DSSQN 156_ AYNED 161_ TSALV 166_ ARLDE 171_ MERGL 176_ FQTGQ 181_ KGLND 186_ FQCWE 191_ KGQAS 196_ QITAS 201_ NLVQN 206_ YKKRK 211_FTDME
1: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232)