Peroxiredoxin-like 2A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) (Protein PAMM) (Redox-regulatory protein FAM213A)
1_MSFLQ 6_ DPSFF 11_ TMGMW 16_ SIGAG 21_ ALGAA 26_ ALALL 31_ LANTD 36_ VFLSK 41_ PQKAA 46_ LEYLE 51_ DIDLK 56_ TLEKE 61_ PRTFK 66_ AKELW 71_ EKNGA 76_ VIMAV 81_ RRPGC 86_ FLCRE 91_ EAADL 96_ SSLKS 101_ MLDQL 106_ GVPLY 111_ AVVKE 116_ HIRTE 121_ VKDFQ 126_ PYFKG 131_ EIFLD 136_ EKKKF 141_ YGPQR 146_ RKMMF 151_ MGFIR 156_ LGVWY 161_ NFFRA 166_ WNGGF 171_ SGNLE 176_ GEGFI 181_ LGGVF 186_ VVGSG 191_ KQGIL 196_ LEHRE 201_ KEFGD 206_ KVNLL 211_ SVLEA 216_ AKMIK 221_PQTLA
1: Involved in redox regulation of the cell (PubMed:19951071, PubMed:26438880). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880)