E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (RING finger protein 109) (Tripartite motif-containing protein 56)
1_MVSHG 6_ SSPSL 11_ LEALS 16_ SDFLA 21_ CKICL 26_ EQLRA 31_ PKTLP 36_ CLHTY 41_ CQDCL 46_ AQLAD 51_ GGRVR 56_ CPECR 61_ ETVPV 66_ PPEGV 71_ ASFKT 76_ NFFVN 81_ GLLDL 86_ VKARA 91_ CGDLR 96_ AGKPA 101_ CALCP 106_ LVGGT 111_ STGGP 116_ ATARC 121_ LDCAD 126_ DLCQA 131_ CADGH 136_ RCTRQ 141_ THTHR 146_ VVDLV 151_ GYRAG 156_ WYDEE 161_ ARERQ 166_ AAQCP 171_ QHPGE 176_ ALRFL 181_ CQPCS 186_ QLLCR 191_ ECRLD 196_ PHLDH 201_ PCLPL 206_ AEAVR 211_ ARRPG 216_ LEGLL 221_ AGVDN 226_ NLVEL 231_ EAARR 236_ VEKEA 241_ LARLR 246_ EQAAR 251_ VGTQV 256_ EEAAE 261_ GVLRA 266_ LLAQK 271_ QEVLG 276_ QLRAH 281_ VEAAE 286_ EAARE 291_ RLAEL 296_ EGREQ 301_ VARAA 306_ AAFAR 311_ RVLSL 316_ GREAE 321_ ILSLE 326_ GAIAQ 331_ RLRQL 336_ QGCPW 341_ APGPA 346_ PCLLP 351_ QLELH 356_ PGLLD 361_ KNCHL 366_ LRLSF 371_ EEQQP 376_ QKDGG 381_ KDGAG 386_ TQGGE 391_ ESQSR 396_ REDEP 401_ KTERQ 406_ GGVQP 411_ QAGDG 416_ AQTPK 421_ EEKAQ 426_ TTREE 431_ GAQTL 436_ EEDRA 441_ QTPHE 446_ DGGPQ 451_ PHRGG 456_ RPNKK 461_ KKFKG 466_ RLKSI 471_ SREPS 476_ PALGP 481_ NLDGS 486_ GLLPR 491_ PIFYC 496_ SFPTR 501_ MPGDK 506_ RSPRI 511_ TGLCP 516_ FGPRE 521_ ILVAD 526_ EQNRA 531_ LKRFS 536_ LNGDY 541_ KGTVP 546_ VPEGC 551_ SPCSV 556_ AALQS 561_ AVAFS 566_ ASARL 571_ YLINP 576_ NGEVQ 581_ WRRAL 586_ SLSQA 591_ SHAVA 596_ ALPSG 601_ DRVAV 606_ SVAGH 611_ VEVYN 616_ MEGSL 621_ ATRFI 626_ PGGKA 631_ SRGLR 636_ ALVFL 641_ TTSPQ 646_ GHFVG 651_ SDWQQ 656_ NSVVI 661_ CDGLG 666_ QVVGE 671_ YKGPG 676_ LHGCQ 681_ PGSVS 686_ VDKKG 691_ YIFLT 696_ LREVN 701_ KVVIL 706_ DPKGS 711_ LLGDF 716_ LTAYH 721_ GLEKP 726_ RVTTM 731_ VDGRY 736_ LVVSL 741_ SNGTI 746_HIFRV
1: E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21289118, PubMed:29426904). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (PubMed:29426904). Promotes also TNFalpha-induced NF-kappa-B signaling by mediating 'Lys-63'-linked ubiquitination TAK1, leading to enhanced interaction between TAK1 and CHUK/IKKalpha (PubMed:35952808). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (PubMed:22948160). Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160). Acts as a restriction factor of Zika virus through direct interaction with the viral RNA via its C-terminal region (PubMed:31251739)