Anaphase-promoting complex subunit 13 (APC13) (Cyclosome subunit 13)
1_MDSEV 6_ QRDGR 11_ ILDLI 16_ DDAWR 21_ EDKLP 26_ YEDVA 31_ IPLNE 36_ LPEPE 41_ QDNGG 46_ TTESV 51_ KEQEM 56_ KWTDL 61_ ALQYL 66_HENVP
1: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:15060174, PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:15060174, PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132)