Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4)
1_MHPAV 6_ FLSLP 11_ DLRCS 16_ LLLLV 21_ TWVFT 26_ PVTTE 31_ ITSLD 36_ TENID 41_ EILNN 46_ ADVAL 51_ VNFYA 56_ DWCRF 61_ SQMLH 66_ PIFEE 71_ ASDVI 76_ KEEFP 81_ NENQV 86_ VFARV 91_ DCDQH 96_ SDIAQ 101_ RYRIS 106_ KYPTL 111_ KLFRN 116_ GMMMK 121_ REYRG 126_ QRSVK 131_ ALADY 136_ IRQQK 141_ SDPIQ 146_ EIRDL 151_ AEITT 156_ LDRSK 161_ RNIIG 166_ YFEQK 171_ DSDNY 176_ RVFER 181_ VANIL 186_ HDDCA 191_ FLSAF 196_ GDVSK 201_ PERYS 206_ GDNII 211_ YKPPG 216_ HSAPD 221_ MVYLG 226_ AMTNF 231_ DVTYN 236_ WIQDK 241_ CVPLV 246_ REITF 251_ ENGEE 256_ LTEEG 261_ LPFLI 266_ LFHMK 271_ EDTES 276_ LEIFQ 281_ NEVAR 286_ QLISE 291_ KGTIN 296_ FLHAD 301_ CDKFR 306_ HPLLH 311_ IQKTP 316_ ADCPV 321_ IAIDS 326_ FRHMY 331_ VFGDF 336_ KDVLI 341_ PGKLK 346_ QFVFD 351_ LHSGK 356_ LHREF 361_ HHGPD 366_ PTDTA 371_ PGEQA 376_ QDVAS 381_ SPPES 386_ SFQKL 391_ APSEY 396_ RYTLL 401_RDRDE
1: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif (PubMed:11847130, PubMed:14517240). Inhibits the calcium channel activity of ITPR1 (PubMed:15652484). May have a role in the control of oxidative protein folding in the endoplasmic reticulum (PubMed:11847130, PubMed:14517240, PubMed:29858230). Required to retain ERO1A and ERO1B in the endoplasmic reticulum (PubMed:11847130, PubMed:29858230)