TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2)
1_MATPL 6_ VAGPA 11_ ALRFA 16_ AAASW 21_ QVVRG 26_ RCVEH 31_ FPRVL 36_ EFLRS 41_ LRAVA 46_ PGLVR 51_ YRHHE 56_ RLCMG 61_ LKAKV 66_ VVELI 71_ LQGRP 76_ WAQVL 81_ KALNH 86_ HFPES 91_ GPIVR 96_ DPKAT 101_ KQDLR 106_ KILEA 111_ QETFY 116_ QQVKQ 121_ LSEAP 126_ VDLAS 131_ KLQEL 136_ EQEYG 141_ EPFLA 146_ AMEKL 151_ LFEYL 156_ CQLEK 161_ ALPTP 166_ QAQQL 171_ QDVLS 176_ WMQPG 181_ VSITS 186_ SLAWR 191_ QYGVD 196_ MGWLL 201_ PECSV 206_ TDSVN 211_ LAEPM 216_ EQNPP 221_ QQQRL 226_ ALHNP 231_ LPKAK 236_ PGTHL 241_ PQGPS 246_ SRTHP 251_ EPLAG 256_ RHFNL 261_ APLGR 266_ RRVQS 271_ QWAST 276_ RGGHK 281_ ERPTV 286_ MLFPF 291_ RNLGS 296_ PTQVI 301_ SKPES 306_ KEEHA 311_ IYTAD 316_ LAMGT 321_ RAAST 326_ GKSKS 331_ PCQTL 336_ GGRAL 341_ KENPV 346_ DLPAT 351_ EQKEN 356_ CLDCY 361_ MDPLR 366_ LSLLP 371_ PRARK 376_ PVCPP 381_ SLCSS 386_ VITIG 391_ DLVLD 396_ SDEEE 401_ NGQGE 406_ GKESL 411_ ENYQK 416_ TKFDT 421_ LIPTL 426_ CEYLP 431_ PSGHG 436_ AIPVS 441_ SCDCR 446_DSSRP
1: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix