Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein)
1_MERSP 6_ GEGPS 11_ PSPMD 16_ QPSAP 21_ SDPTD 26_ QPPAA 31_ HAKPD 36_ PGSGG 41_ QPAGP 46_ GAAGE 51_ ALAVL 56_ TSFGR 61_ RLLVL 66_ IPVYL 71_ AGAVG 76_ LSVGF 81_ VLFGL 86_ ALYLG 91_ WRRVR 96_ DEKER 101_ SLRAA 106_ RQLLD 111_ DEEQL 116_ TAKTL 121_ YMSHR 126_ ELPAW 131_ VSFPD 136_ VEKAE 141_ WLNKI 146_ VAQVW 151_ PFLGQ 156_ YMEKL 161_ LAETV 166_ APAVR 171_ GSNPH 176_ LQTFT 181_ FTRVE 186_ LGEKP 191_ LRIIG 196_ VKVHP 201_ GQRKE 206_ QILLD 211_ LNISY 216_ VGDVQ 221_ IDVEV 226_ KKYFC 231_ KAGVK 236_ GMQLH 241_ GVLRV 246_ ILEPL 251_ IGDLP 256_ FVGAV 261_ SMFFI 266_ RRPTL 271_ DINWT 276_ GMTNL 281_ LDIPG 286_ LSSLS 291_ DTMIM 296_ DSIAA 301_ FLVLP 306_ NRLLV 311_ PLVPD 316_ LQDVA 321_ QLRSP 326_ LPRGI 331_ IRIHL 336_ LAARG 341_ LSSKD 346_ KYVKG 351_ LIEGK 356_ SDPYA 361_ LVRLG 366_ TQTFC 371_ SRVID 376_ EELNP 381_ QWGET 386_ YEVMV 391_ HEVPG 396_ QEIEV 401_ EVFDK 406_ DPDKD 411_ DFLGR 416_ MKLDV 421_ GKVLQ 426_ ASVLD 431_ DWFPL 436_ QGGQG 441_ QVHLR 446_ LEWLS 451_ LLSDA 456_ EKLEQ 461_ VLQWN 466_ WGVSS 471_ RPDPP 476_ SAAIL 481_ VVYLD 486_ RAQDL 491_ PLKKG 496_ NKEPN 501_ PMVQL 506_ SIQDV 511_ TQESK 516_ AVYST 521_ NCPVW 526_ EEAFR 531_ FFLQD 536_ PQSQE 541_ LDVQV 546_ KDDSR 551_ ALTLG 556_ ALTLP 561_ LARLL 566_ TAPEL 571_ ILDQW 576_ FQLSS 581_ SGPNS 586_ RLYMK 591_ LVMRI 596_ LYLDS 601_ SEICF 606_ PTVPG 611_ CPGAW 616_ DVDSE 621_ NPQRG 626_ SSVDA 631_ PPRPC 636_ HTTPD 641_ SQFGT 646_ EHVLR 651_ IHVLE 656_ AQDLI 661_ AKDRF 666_ LGGLV 671_ KGKSD 676_ PYVKL 681_ KLAGR 686_ SFRSH 691_ VVRED 696_ LNPRW 701_ NEVFE 706_ VIVTS 711_ VPGQE 716_ LEVEV 721_ FDKDL 726_ DKDDF 731_ LGRCK 736_ VRLTT 741_ VLNSG 746_ FLDEW 751_ LTLED 756_ VPSGR 761_ LHLRL 766_ ERLTP 771_ RPTAA 776_ ELEEV 781_ LQVNS 786_ LIQTQ 791_ KSAEL 796_ AAALL 801_ SIYME 806_ RAEDL 811_ PLRKG 816_ TKHLS 821_ PYATL 826_ TVGDS 831_ SHKTK 836_ TISQT 841_ SAPVW 846_ DESAS 851_ FLIRK 856_ PHTES 861_ LELQV 866_ RGEGT 871_ GVLGS 876_ LSLPL 881_ SELLV 886_ ADQLC 891_ LDRWF 896_ TLSSG 901_ QGQVL 906_ LRAQL 911_ GILVS 916_ QHSGV 921_ EAHSH 926_ SYSHS 931_ SSSLS 936_ EEPEL 941_ SGGPP 946_ HITSS 951_ APELR 956_ QRLTH 961_ VDSPL 966_ EAPAG 971_ PLGQV 976_ KLTLW 981_ YYSEE 986_ RKLVS 991_ IVHGC 996_ RSLRQ 1001_ NGRDP 1006_ PDPYV 1011_ SLLLL 1016_ PDKNR 1021_ GTKRR 1026_ TSQKK 1031_ RTLSP 1036_ EFNER 1041_ FEWEL 1046_ PLDEA 1051_ QRRKL 1056_ DVSVK 1061_ SNSSF 1066_ MSRER 1071_ ELLGK 1076_ VQLDL 1081_ AETDL 1086_ SQGVA 1091_ RWYDL 1096_MDNKD
1: Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity)