Solute carrier family 25 member 33 (Bone marrow stromal cell mitochondrial carrier protein) (BMSC-MCP) (HuBMSC-MCP) (Protein PNC1)
1_MATGG 6_ QQKEN 11_ TLLHL 16_ FAGGC 21_ GGTVG 26_ AIFTC 31_ PLEVI 36_ KTRLQ 41_ SSRLA 46_ LRTVY 51_ YPQVH 56_ LGTIS 61_ GAGMV 66_ RPTSV 71_ TPGLF 76_ QVLKS 81_ ILEKE 86_ GPKSL 91_ FRGLG 96_ PNLVG 101_ VAPSR 106_ AVYFA 111_ CYSKA 116_ KEQFN 121_ GIFVP 126_ NSNIV 131_ HIFSA 136_ GSAAF 141_ ITNSL 146_ MNPIW 151_ MVKTR 156_ MQLEQ 161_ KVRGS 166_ KQMNT 171_ LQCAR 176_ YVYQT 181_ EGIRG 186_ FYRGL 191_ TASYA 196_ GISET 201_ IICFA 206_ IYESL 211_ KKYLK 216_ EAPLA 221_ SSANG 226_ TEKNS 231_ TSFFG 236_ LMAAA 241_ ALSKG 246_ CASCI 251_ AYPHE 256_ VIRTR 261_ LREEG 266_ TKYKS 271_ FVQTA 276_ RLVFR 281_ EEGYL 286_ AFYRG 291_ LFAQL 296_ IRQIP 301_ NTAIV 306_ LSTYE 311_ LIVYL 316_LEDRT
1: Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports uridine, thymidine, guanosine, cytosine and inosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (PubMed:25320081). May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism (PubMed:25320081). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (PubMed:20453889). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:17596519, PubMed:20453889). Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (PubMed:14715278)