Protein fem-1 homolog A (FEM1a) (FEM1-alpha) (Prostaglandin E receptor 4-associated protein)
1_MDLRT 6_ AVYNA 11_ ARDGK 16_ LQLLQ 21_ KLLSG 26_ RSREE 31_ LDELT 36_ GEVAG 41_ GGTPL 46_ LIAAR 51_ YGHLD 56_ VVEYL 61_ VDRCG 66_ ASVEA 71_ GGSVH 76_ FDGET 81_ IEGAP 86_ PLWAA 91_ SAAGH 96_ LDVVR 101_ SLLRR 106_ GASVN 111_ RTTRT 116_ NSTPL 121_ RAACF 126_ DGHLE 131_ VVRYL 136_ VGEHQ 141_ ADLEV 146_ ANRHG 151_ HTCLM 156_ ISCYK 161_ GHREI 166_ ARYLL 171_ EQGAQ 176_ VNRRS 181_ AKGNT 186_ ALHDC 191_ AESGS 196_ LEILQ 201_ LLLGC 206_ KARME 211_ RDGYG 216_ MTPLL 221_ AASVT 226_ GHTNI 231_ VEYLI 236_ QEQPG 241_ QEQVA 246_ GGEAQ 251_ PGLPQ 256_ EDPST 261_ SQGCA 266_ QPQGA 271_ PCCSS 276_ SPEEP 281_ LNGES 286_ YESCC 291_ PTSRE 296_ AAVEA 301_ LELLG 306_ ATYVD 311_ KKRDL 316_ LGALK 321_ HWRRA 326_ MELRH 331_ QGGEY 336_ LPKPE 341_ PPQLV 346_ LAYDY 351_ SREVN 356_ TTEEL 361_ EALIT 366_ DPDEM 371_ RMQAL 376_ LIRER 381_ ILGPS 386_ HPDTS 391_ YYIRY 396_ RGAVY 401_ ADSGN 406_ FERCI 411_ RLWKY 416_ ALDMQ 421_ QSNLE 426_ PLSPM 431_ TASSF 436_ LSFAE 441_ LFSYV 446_ LQDRA 451_ AKGSL 456_ GTQIG 461_ FADLM 466_ GVLTK 471_ GVREV 476_ ERALQ 481_ LPREP 486_ GDSAQ 491_ FTKAL 496_ AIILH 501_ LLYLL 506_ EKVEC 511_ TPSQE 516_ HLKHQ 521_ TVYRL 526_ LKCAP 531_ RGKNG 536_ FTPLH 541_ MAVDK 546_ DTTNV 551_ GRYPV 556_ GRFPS 561_ LHVVK 566_ VLLDC 571_ GADPD 576_ SRDFD 581_ NNTPL 586_ HIAAQ 591_ NNCPA 596_ IMNAL 601_ IEAGA 606_ HMDAT 611_ NAFKK 616_ TAYEL 621_ LDEKL 626_ LARGT 631_ MQPFN 636_ YVTLQ 641_ CLAAR 646_ ALDKN 651_ KIPYK 656_ GFIPE 661_DLEAF
1: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:33398168, PubMed:33398170). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:33398168, PubMed:33398170). The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (PubMed:33398168, PubMed:33398170). Promotes ubiquitination and degradation of SLBP (PubMed:28118078). Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4 (By similarity). Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity)