Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (E3 ubiquitin-protein ligase subunit KPC2) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2)
1_MFVQE 6_ EKIFA 11_ GKVLR 16_ LHICA 21_ SDGAE 26_ WLEEA 31_ TEDTS 36_ VEKLK 41_ ERCLK 46_ HCAHG 51_ SLEDP 56_ KSITH 61_ HKLIH 66_ AASER 71_ VLSDA 76_ RTILE 81_ ENIQD 86_ QDVLL 91_ LIKKR 96_ APSPL 101_ PKMAD 106_ VSAEE 111_ KKKQD 116_ QKAPD 121_ KEAIL 126_ RATAN 131_ LPSYN 136_ MDRAA 141_ VQTNM 146_ RDFQT 151_ ELRKI 156_ LVSLI 161_ EVAQK 166_ LLALN 171_ PDAVE 176_ LFKKA 181_ NAMLD 186_ EDEDE 191_ RVDEA 196_ ALRQL 201_ TEMGF 206_ PENRA 211_ TKALQ 216_ LNHMS 221_ VPQAM 226_ EWLIE 231_ HAEDP 236_ TIDTP 241_ LPGQA 246_ PPEAE 251_ GATAA 256_ ASEAA 261_ AGASA 266_ TDEEA 271_ RDELT 276_ EIFKK 281_ IRRKR 286_ EFRAD 291_ ARAVI 296_ SLMEM 301_ GFDEK 306_ EVIDA 311_ LRVNN 316_ NQQNA 321_ ACEWL 326_ LGDRK 331_ PSPEE 336_ LDKGI 341_ DPDSP 346_ LFQAI 351_ LDNPV 356_ VQLGL 361_ TNPKT 366_ LLAFE 371_ DMLEN 376_ PLNST 381_ QWMND 386_ PETGP 391_ VMLQI 396_SRIFQ
1: Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1 (PubMed:15531880, PubMed:15746103, PubMed:16227581, PubMed:25860612). The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (PubMed:15531880, PubMed:15746103). The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor (PubMed:25860612). Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome (PubMed:16227581)