Cerebral cavernous malformations 2 protein (Malcavernin)
1_MEEEG 6_ KKGKK 11_ PGIVS 16_ PFKRV 21_ FLKGE 26_ KSRDK 31_ KAHEK 36_ VTERR 41_ PLHTV 46_ VLSLP 51_ ERVEP 56_ DRLLS 61_ DYIEK 66_ EVKYL 71_ GQLTS 76_ IPGYL 81_ NPSSR 86_ TEILH 91_ FIDNA 96_ KRAHQ 101_ LPGHL 106_ TQEHD 111_ AVLSL 116_ SAYNV 121_ KLAWR 126_ DGEDI 131_ ILRVP 136_ IHDIA 141_ AVSYV 146_ RDDAA 151_ HLVVL 156_ KTAQD 161_ PGISP 166_ SQSLC 171_ AESSR 176_ GLSAG 181_ SLSES 186_ AVGPV 191_ EACCL 196_ VILAA 201_ ESKVA 206_ AEELC 211_ CLLGQ 216_ VFQVV 221_ YTEST 226_ IDFLD 231_ RAIFD 236_ GASTP 241_ THHLS 246_ LHSDD 251_ SSTKV 256_ DIKET 261_ YEVEA 266_ STFCF 271_ PESVD 276_ VGGAS 281_ PHSKT 286_ ISESE 291_ LSASA 296_ TELLQ 301_ DYMLT 306_ LRTKL 311_ SSQEI 316_ QQFAA 321_ LLHEY 326_ RNGAS 331_ IHEFC 336_ INLRQ 341_ LYGDS 346_ RKFLL 351_ LGLRP 356_ FIPEK 361_ DSQHF 366_ ENFLE 371_ TIGVK 376_ DGRGI 381_ ITDSF 386_ GRHRR 391_ ALSTT 396_ SSSTT 401_ NGNRA 406_ TGSSD 411_ DRSAP 416_ SEGDE 421_ WDRMI 426_ SDISS 431_ DIEAL 436_GCSMD
1: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity)