EF-hand calcium-binding domain-containing protein 4B (Calcium release-activated calcium channel regulator 2A) (CRAC channel regulator 2A) (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46)
1_MAAPD 6_ GRVVS 11_ RPQRL 16_ GQGSG 21_ QGPKG 26_ SGACL 31_ HPLDS 36_ LEQKE 41_ TQEQT 46_ SGQLV 51_ MLRKA 56_ QEFFQ 61_ TCDAE 66_ GKGFI 71_ ARKDM 76_ QRLHK 81_ ELPLS 86_ LEELE 91_ DVFDA 96_ LDADG 101_ NGYLT 106_ PQEFT 111_ TGFSH 116_ FFFSQ 121_ NNPSQ 126_ EDAGE 131_ QVAQR 136_ HEEKV 141_ YLSRG 146_ DEDLG 151_ DMGED 156_ EEAQF 161_ RMLMD 166_ RLGAQ 171_ KVLED 176_ ESDVK 181_ QLWLQ 186_ LKKEE 191_ PHLLS 196_ NFEDF 201_ LTRII 206_ SQLQE 211_ AHEEK 216_ NELEC 221_ ALKRK 226_ IAAYD 231_ EEIQH 236_ LYEEM 241_ EQQIK 246_ SEKEQ 251_ FLLKD 256_ TERFQ 261_ ARSQE 266_ LEQKL 271_ LCKEQ 276_ ELEQL 281_ TQKQK 286_ RLEGQ 291_ CTALH 296_ HDKHE 301_ TKAEN 306_ TKLKL 311_ TNQEL 316_ ARELE 321_ RTSWE 326_ LQDAQ 331_ QQLES 336_ LQQEA 341_ CKLHQ 346_ EKEME 351_ VYRVT 356_ ESLQR 361_ EKAGL 366_ LKQLD 371_ FLRER 376_ NKHLR 381_ DERDI 386_ CFQKN 391_ KAAKA 396_ NTAAS 401_ RASWK 406_ KRSGS 411_ VIGKY 416_ VDSRG 421_ ILRSQ 426_ SEEEE 431_ EVFGI 436_ PRRSS 441_ LGLSG 446_ YPLTE 451_ EEPGT 456_ GEPGP 461_ GGPYP 466_ RPLRR 471_ IISVE 476_ EDPLP 481_ QLLDG 486_ GFEQP 491_ LSKCS 496_ EEEEV 501_ SDQGV 506_ QGQIP 511_ EAPPL 516_ KLTPT 521_ SPRGQ 526_ PVGKE 531_ ALCKE 536_ ESSPS 541_ APDRL 546_ FKIVF 551_ VGNSA 556_ VGKTS 561_ FLRRF 566_ CEDRF 571_ SPGMA 576_ ATVGI 581_ DYRVK 586_ TLNVD 591_ NSQVA 596_ LQLWD 601_ TAGQE 606_ RYRCI 611_ TQQFF 616_ RKADG 621_ VIVMY 626_ DLTDK 631_ QSFLS 636_ VRRWL 641_ SSVEE 646_ AVGDR 651_ VPVLL 656_ LGNKL 661_ DNEKE 666_ REVPR 671_ GLGEQ 676_ LATEN 681_ NLIFY 686_ ECSAY 691_ SGHNT 696_ KESLL 701_ HLARF 706_ LKEQE 711_ DTVRE 716_ DTIQV 721_ GHPAK 726_KKSCC
1: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex
2: Rab GTPase that mediates the trafficking of Weibel-Palade bodies (WPBs) to microtubule organizing center (MTOC) in endothelial cells in response to acute inflammatory stimuli (PubMed:31092558). During histamine (but not thrombin) stimulation of endothelial cells, the dynein-bound form induces retrograde transport of a subset of WPBs along microtubules to the MTOC in a Ca(2+)-independent manner and its GTPase activity is essential for this function (PubMed:31092558). Ca(2+)-regulated dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules and regulates endosomal trafficking of CD47 (PubMed:30814157). Acts as an intracellular signaling module bridging two important T-cell receptor (TCR) signaling pathways, Ca(2+)-NFAT and JNK, to affect T-cell activation (PubMed:27016526). In resting T-cells, is predominantly localized near TGN network in a GTP-bound form, upon TCR stimulation, localizes at the immunological synapse via interaction with VAV1 to activate downstream Ca(2+)-NFAT and JNK signaling pathways (PubMed:27016526). Plays a role in T-helper 1 (Th1) cell differentiation and T-helper 17 (Th17) cell effector function (PubMed:29987160). Plays a role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation (PubMed:27016526)