Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2) (DeSI-2) (PPPDE peptidase domain-containing protein 1) (Protein FAM152A)
1_MGANQ 6_ LVVLN 11_ VYDMY 16_ WMNEY 21_ TSSIG 26_ IGVFH 31_ SGIEV 36_ YGREF 41_ AYGGH 46_ PYPFS 51_ GIFEI 56_ SPGNA 61_ SELGE 66_ TFKFK 71_ EAVVL 76_ GSTDF 81_ LEDDI 86_ EKIVE 91_ ELGKE 96_ YKGNA 101_ YHLMH 106_ KNCNH 111_ FSSAL 116_ SEILC 121_ GKEIP 126_ RWINR 131_ LAYFS 136_ SCIPF 141_ LQSCL 146_ PKEWL 151_ TPAAL 156_ QSSVS 161_ QELQD 166_ ELEEA 171_ EDAAA 176_ SASVA 181_ STAAG 186_SRPGR
1: Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization (PubMed:28483520). Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5) (PubMed:35427157)