Chitobiosyldiphosphodolichol beta-mannosyltransferase (EC 2.4.1.142) (Asparagine-linked glycosylation protein 1 homolog) (Beta-1,4-mannosyltransferase) (GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase) (GDP-mannose-dolichol diphosphochitobiose mannosyltransferase) (Mannosyltransferase-1) (MT-1) (hMat-1)
1_MAASC 6_ LVLLA 11_ LCLLL 16_ PLLLL 21_ GGWKR 26_ WRRGR 31_ AARHV 36_ VAVVL 41_ GDVGR 46_ SPRMQ 51_ YHALS 56_ LAMHG 61_ FSVTL 66_ LGFCN 71_ SKPHD 76_ ELLQN 81_ NRIQI 86_ VGLTE 91_ LQSLA 96_ VGPRV 101_ FQYGV 106_ KVVLQ 111_ AMYLL 116_ WKLMW 121_ REPGA 126_ YIFLQ 131_ NPPGL 136_ PSIAV 141_ CWFVG 146_ CLCGS 151_ KLVID 156_ WHNYG 161_ YSIMG 166_ LVHGP 171_ NHPLV 176_ LLAKW 181_ YEKFF 186_ GRLSH 191_ LNLCV 196_ TNAMR 201_ EDLAD 206_ NWHIR 211_ AVTVY 216_ DKPAS 221_ FFKET 226_ PLDLQ 231_ HRLFM 236_ KLGSM 241_ HSPFR 246_ ARSEP 251_ EDPVT 256_ ERSAF 261_ TERDA 266_ GSGLV 271_ TRLRE 276_ RPALL 281_ VSSTS 286_ WTEDE 291_ DFSIL 296_ LAALE 301_ KFEQL 306_ TLDGH 311_ NLPSL 316_ VCVIT 321_ GKGPL 326_ REYYS 331_ RLIHQ 336_ KHFQH 341_ IQVCT 346_ PWLEA 351_ EDYPL 356_ LLGSA 361_ DLGVC 366_ LHTSS 371_ SGLDL 376_ PMKVV 381_ DMFGC 386_ CLPVC 391_ AVNFK 396_ CLHEL 401_ VKHEE 406_ NGLVF 411_ EDSEE 416_ LAAQL 421_ QMLFS 426_ NFPDP 431_ AGKLN 436_ QFRKN 441_ LRESQ 446_ QLRWD 451_ ESWVQ 456_TVLPL
1: Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the first mannose residues to the dolichol-linked oligosaccharide chain, to produce Man1GlcNAc(2)-PP-dolichol core oligosaccharide. Man1GlcNAc(2)-PP-dolichol is a substrate for ALG2, the following enzyme in the biosynthetic pathway