Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 7) (Spermatogenesis cell proliferation-related protein) (Spermatogenesis-associated protein 11)
1_MAGTG 6_ LLALR 11_ TLPGP 16_ SWVRG 21_ SGPSV 26_ LSRLQ 31_ DAAVV 36_ RPGFL 41_ STAEE 46_ ETLSR 51_ ELEPE 56_ LRRRR 61_ YEYDH 66_ WDAAI 71_ HGFRE 76_ TEKSR 81_ WSEAS 86_ RAILQ 91_ RVQAA 96_ AFGPG 101_ QTLLS 106_ SVHVL 111_ DLEAR 116_ GYIKP 121_ HVDSI 126_ KFCGA 131_ TIAGL 136_ SLLSP 141_ SVMRL 146_ VHTQE 151_ PGEWL 156_ ELLLE 161_ PGSLY 166_ ILRGS 171_ ARYDF 176_ SHEIL 181_ RDEES 186_ FFGER 191_ RIPRG 196_ RRISV 201_ ICRSL 206_ PEGMG 211_ PGESG 216_QPPPA
1: May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity)