Inositol polyphosphate 5-phosphatase K (EC 3.1.3.56) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Skeletal muscle and kidney-enriched inositol phosphatase)
1_MSSRK 6_ LSGPK 11_ GRRLS 16_ IHVVT 21_ WNVAS 26_ AAPPL 31_ DLSDL 36_ LQLNN 41_ RNLNL 46_ DIYVI 51_ GLQEL 56_ NSGII 61_ SLLSD 66_ AAFND 71_ SWSSF 76_ LMDVL 81_ SPLSF 86_ IKVSH 91_ VRMQG 96_ ILLLV 101_ FAKYQ 106_ HLPYI 111_ QILST 116_ KSTPT 121_ GLFGY 126_ WGNKG 131_ GVNIC 136_ LKLYG 141_ YYVSI 146_ INCHL 151_ PPHIS 156_ NNYQR 161_ LEHFD 166_ RILEM 171_ QNCEG 176_ RDIPN 181_ ILDHD 186_ LIIWF 191_ GDMNF 196_ RIEDF 201_ GLHFV 206_ RESIK 211_ NRCYG 216_ GLWEK 221_ DQLSI 226_ AKKHD 231_ PLLRE 236_ FQEGR 241_ LLFPP 246_ TYKFD 251_ RNSND 256_ YDTSE 261_ KKRKP 266_ AWTDR 271_ ILWRL 276_ KRQPC 281_ AGPDT 286_ PIPPA 291_ SHFSL 296_ SLRGY 301_ SSHMT 306_ YGISD 311_ HKPVS 316_ GTFDL 321_ ELKPL 326_ VSAPL 331_ IVLMP 336_ EDLWT 341_ VENDM 346_ MVSYS 351_ STSDF 356_ PSSPW 361_ DWIGL 366_ YKVGL 371_ RDVND 376_ YVSYA 381_ WVGDS 386_ KVSCS 391_ DNLNQ 396_ VYIDI 401_ SNIPT 406_ TEDEF 411_ LLCYY 416_ SNSLR 421_ SVVGI 426_ SRPFQ 431_ IPPGS 436_ LREDP 441_LGEAQ
1: Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (PubMed:10753883, PubMed:16824732). Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (PubMed:10753883). Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity)