Spexin (NPQ) (Neuropeptide Q) (Spexin hormone) [Cleaved into: Spexin-1; Spexin-2 (NPQ 53-70)]
1_MKGLR 6_ SLAAT 11_ TLALF 16_ LVFVF 21_ LGNSS 26_ CAPQR 31_ LLERR 36_ NWTPQ 41_ AMLYL 46_ KGAQG 51_ RRFIS 56_ DQSRR 61_ KDLSD 66_ RPLPE 71_ RRSPN 76_ PQLLT 81_ IPEAA 86_ TILLA 91_ SLQKS 96_ PEDEE 101_ KNFDQ 106_ TRFLE 111_DSLLN
1: Plays a role as a central modulator of cardiovascular and renal function and nociception. Also plays a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity)
2: Acts as a ligand for galanin receptors GALR2 and GALR3 (PubMed:17284679, PubMed:24517231). Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity)
3: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity)