COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4)
1_MAAAV 6_ RQDLA 11_ QLMNS 16_ SGSHK 21_ DLAGK 26_ YRQIL 31_ EKAIQ 36_ LSGAE 41_ QLEAL 46_ KAFVE 51_ AMVNE 56_ NVSLV 61_ ISRQL 66_ LTDFC 71_ THLPN 76_ LPDST 81_ AKEIY 86_ HFTLE 91_ KIQPR 96_ VISFE 101_ EQVAS 106_ IRQHL 111_ ASIYE 116_ KEEDW 121_ RNAAQ 126_ VLVGI 131_ PLETG 136_ QKQYN 141_ VDYKL 146_ ETYLK 151_ IARLY 156_ LEDDD 161_ PVQAE 166_ AYINR 171_ ASLLQ 176_ NESTN 181_ EQLQI 186_ HYKVC 191_ YARVL 196_ DYRRK 201_ FIEAA 206_ QRYNE 211_ LSYKT 216_ IVHES 221_ ERLEA 226_ LKHAL 231_ HCTIL 236_ ASAGQ 241_ QRSRM 246_ LATLF 251_ KDERC 256_ QQLAA 261_ YGILE 266_ KMYLD 271_ RIIRG 276_ NQLQE 281_ FAAML 286_ MPHQK 291_ ATTAD 296_ GSSIL 301_ DRAVI 306_ EHNLL 311_ SASKL 316_ YNNIT 321_ FEELG 326_ ALLEI 331_ PAAKA 336_ EKIAS 341_ QMITE 346_ GRMNG 351_ FIDQI 356_ DGIVH 361_ FETRE 366_ ALPTW 371_ DKQIQ 376_ SLCFQ 381_ VNNLL 386_ EKISQ 391_ TAPEW 396_ TAQAM 401_EAQMA
1: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively