Transcription factor SOX-7
1_MASLL 6_ GAYPW 11_ PEGLE 16_ CPALD 21_ AELSD 26_ GQSPP 31_ AVPRP 36_ PGDKG 41_ SESRI 46_ RRPMN 51_ AFMVW 56_ AKDER 61_ KRLAV 66_ QNPDL 71_ HNAEL 76_ SKMLG 81_ KSWKA 86_ LTLSQ 91_ KRPYV 96_ DEAER 101_ LRLQH 106_ MQDYP 111_ NYKYR 116_ PRRKK 121_ QAKRL 126_ CKRVD 131_ PGFLL 136_ SSLSR 141_ DQNAL 146_ PEKRS 151_ GSRGA 156_ LGEKE 161_ DRGEY 166_ SPGTA 171_ LPSLR 176_ GCYHE 181_ GPAGG 186_ GGGGT 191_ PSSVD 196_ TYPYG 201_ LPTPP 206_ EMSPL 211_ DVLEP 216_ EQTFF 221_ SSPCQ 226_ EEHGH 231_ PRRIP 236_ HLPGH 241_ PYSPE 246_ YAPSP 251_ LHCSH 256_ PLGSL 261_ ALGQS 266_ PGVSM 271_ MSPVP 276_ GCPPS 281_ PAYYS 286_ PATYH 291_ PLHSN 296_ LQAHL 301_ GQLSP 306_ PPEHP 311_ GFDAL 316_ DQLSQ 321_ VELLG 326_ DMDRN 331_ EFDQY 336_ LNTPG 341_ HPDSA 346_ TGAMA 351_ LSGHV 356_ PVSQV 361_ TPTGP 366_ TETSL 371_ ISVLA 376_ DATAT 381_YYNSY
1: Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'