Synaptotagmin-11 (Synaptotagmin XI) (SytXI)
1_MAEIT 6_ NIRPS 11_ FDVSP 16_ VVAGL 21_ IGASV 26_ LVVCV 31_ SVTVF 36_ VWSCC 41_ HQQAE 46_ KKQKN 51_ PPYKF 56_ IHMLK 61_ GISIY 66_ PETLS 71_ NKKKI 76_ IKVRR 81_ DKDGP 86_ GREGG 91_ RRNLL 96_ VDAAE 101_ AGLLS 106_ RDKDP 111_ RGPSS 116_ GSCID 121_ QLPIK 126_ MDYGE 131_ ELRSP 136_ ITSLT 141_ PGESK 146_ TTSPS 151_ SPEED 156_ VMLGS 161_ LTFSV 166_ DYNFP 171_ KKALV 176_ VTIQE 181_ AHGLP 186_ VMDDQ 191_ TQGSD 196_ PYIKM 201_ TILPD 206_ KRHRV 211_ KTRVL 216_ RKTLD 221_ PVFDE 226_ TFTFY 231_ GIPYS 236_ QLQDL 241_ VLHFL 246_ VLSFD 251_ RFSRD 256_ DVIGE 261_ VMVPL 266_ AGVDP 271_ STGKV 276_ QLTRD 281_ IIKRN 286_ IQKCI 291_ SRGEL 296_ QVSLS 301_ YQPVA 306_ QRMTV 311_ VVLKA 316_ RHLPK 321_ MDITG 326_ LSGNP 331_ YVKVN 336_ VYYGR 341_ KRIAK 346_ KKTHV 351_ KKCTL 356_ NPIFN 361_ ESFIY 366_ DIPTD 371_ LLPDI 376_ SIEFL 381_ VIDFD 386_ RTTKN 391_ EVVGR 396_ LILGA 401_ HSVTA 406_ SGAEH 411_ WREVC 416_ ESPRK 421_ PVAKW 426_HSLSE
1: Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (By similarity). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed:27278822)