Trichoplein keratin filament-binding protein (Protein TCHP) (Mitochondrial protein with oncostatic activity) (Mitostatin) (Tumor suppressor protein)
1_MALPT 6_ LPSYW 11_ CSQQR 16_ LNQQL 21_ ARQRE 26_ QEARL 31_ RQQWE 36_ QNSRY 41_ FRMSD 46_ ICSSK 51_ QAEWS 56_ SKTSY 61_ QRSMH 66_ AYQRE 71_ KMKEE 76_ KRRSL 81_ EARRE 86_ KLRQL 91_ MQEEQ 96_ DLLAR 101_ ELEEL 106_ RLSMN 111_ LQERR 116_ IREQH 121_ GKLKS 126_ AKEEQ 131_ RKLIA 136_ EQLLY 141_ EHWKK 146_ NNPKL 151_ REMEL 156_ DLHQK 161_ HVVNS 166_ WEMQK 171_ EEKKQ 176_ QEATA 181_ EQENK 186_ RYENE 191_ YERAR 196_ REALE 201_ RMKAE 206_ EERRQ 211_ LEDKL 216_ QAEAL 221_ LQQME 226_ ELKLK 231_ EVEAT 236_ KLKKE 241_ QENLL 246_ KQRWE 251_ LERLE 256_ EERKQ 261_ MEAFR 266_ QKAEL 271_ GRFLR 276_ HQYNA 281_ QLSRR 286_ TQQIQ 291_ EELEA 296_ DRRIL 301_ QALLE 306_ KEDES 311_ QRLHL 316_ ARREQ 321_ VMADV 326_ AWMKQ 331_ AIEEQ 336_ LQLER 341_ AREAE 346_ LQMLL 351_ REEAK 356_ EMWEK 361_ REAEW 366_ ARERS 371_ ARDRL 376_ MSEVL 381_ TGRQQ 386_ QIQEK 391_ IEQNR 396_ RAQEE 401_ SLKHR 406_ EQLIR 411_ NLEEV 416_ RELAR 421_ REKEE 426_ SEKLK 431_ SARKQ 436_ ELEAQ 441_ VAERR 446_ LQAWE 451_ ADQQE 456_ EEEEE 461_ EARRV 466_ EQLSD 471_ ALLQQ 476_ EAETM 481_ AEQGY 486_ RPKPY 491_GHPKI
1: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701). Is a negative regulator of ciliogenesis (PubMed:25270598)