WW domain-containing adapter protein with coiled-coil
1_MVMYA 6_ RKQQR 11_ LSDGC 16_ HDRRG 21_ DSQPY 26_ QALKY 31_ SSKSH 36_ PSSGD 41_ HRHEK 46_ MRDAG 51_ DPSPP 56_ NKMLR 61_ RSDSP 66_ ENKYS 71_ DSTGH 76_ SKAKN 81_ VHTHR 86_ VRERD 91_ GGTSY 96_ SPQEN 101_ SHNHS 106_ ALHSS 111_ NSHSS 116_ NPSNN 121_ PSKTS 126_ DAPYD 131_ SADDW 136_ SEHIS 141_ SSGKK 146_ YYYNC 151_ RTEVS 156_ QWEKP 161_ KEWLE 166_ REQRQ 171_ KEANK 176_ MAVNS 181_ FPKDR 186_ DYRRE 191_ VMQAT 196_ ATSGF 201_ ASGME 206_ DKHSS 211_ DASSL 216_ LPQNI 221_ LSQTS 226_ RHNDR 231_ DYRLP 236_ RAETH 241_ SSSTP 246_ VQHPI 251_ KPVVH 256_ PTATP 261_ STVPS 266_ SPFTL 271_ QSDHQ 276_ PKKSF 281_ DANGA 286_ STLSK 291_ LPTPT 296_ SSVPA 301_ QKTER 306_ KESTS 311_ GDKPV 316_ SHSCT 321_ TPSTS 326_ SASGL 331_ NPTSA 336_ PPTSA 341_ SAVPV 346_ SPVPQ 351_ SPIPP 356_ LLQDP 361_ NLLRQ 366_ LLPAL 371_ QATLQ 376_ LNNSN 381_ VDISK 386_ INEVL 391_ TAAVT 396_ QASLQ 401_ SIIHK 406_ FLTAG 411_ PSAFN 416_ ITSLI 421_ SQAAQ 426_ LSTQA 431_ QPSNQ 436_ SPMSL 441_ TSDAS 446_ SPRSY 451_ VSPRI 456_ STPQT 461_ NTVPI 466_ KPLIS 471_ TPPVS 476_ SQPKV 481_ STPVV 486_ KQGPV 491_ SQSAT 496_ QQPVT 501_ ADKQQ 506_ GHEPV 511_ SPRSL 516_ QRSSS 521_ QRSPS 526_ PGPNH 531_ TSNSS 536_ NASNA 541_ TVVPQ 546_ NSSAR 551_ STCSL 556_ TPALA 561_ AHFSE 566_ NLIKH 571_ VQGWP 576_ ADHAE 581_ KQASR 586_ LREEA 591_ HNMGT 596_ IHMSE 601_ ICTEL 606_ KNLRS 611_ LVRVC 616_ EIQAT 621_ LREQR 626_ ILFLR 631_ QQIKE 636_ LEKLK 641_NQNSF
1: Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877)