DCN1-like protein 5 (DCNL5) (DCUN1 domain-containing protein 5) (Defective in cullin neddylation protein 1-like protein 5) (Squamous cell carcinoma-related oncogene 5)
1_MPVKK 6_ KRKSP 11_ GVAAA 16_ VAEDG 21_ GLKKC 26_ KISSY 31_ CRSQP 36_ PARLI 41_ SGEEH 46_ FSSKK 51_ CLAWF 56_ YEYAG 61_ PDEVV 66_ GPEGM 71_ EKFCE 76_ DIGVE 81_ PENII 86_ MLVLA 91_ WKLEA 96_ ESMGF 101_ FTKEE 106_ WLKGM 111_ TSLQC 116_ DCTEK 121_ LQNKF 126_ DFLRS 131_ QLNDI 136_ SSFKN 141_ IYRYA 146_ FDFAR 151_ DKDQR 156_ SLDID 161_ TAKSM 166_ LALLL 171_ GRTWP 176_ LFSVF 181_ YQYLE 186_ QSKYR 191_ VMNKD 196_ QWYNV 201_ LEFSR 206_ TVHAD 211_ LSNYD 216_ EDGAW 221_ PVLLD 226_ EFVEW 231_QKVRQ
1: Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs) (PubMed:19617556, PubMed:23201271, PubMed:26906416). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth (PubMed:23098533, PubMed:24192928)