THUMP domain-containing protein 2
1_MSEAR 6_ GEPGS 11_ GPEAG 16_ ARFFC 21_ TAGRG 26_ LEPFV 31_ MREVR 36_ ARLAA 41_ TQVEY 46_ ISGKV 51_ FFTTC 56_ SDLNM 61_ LKKLK 66_ SAERL 71_ FLLIK 76_ KQFPL 81_ IISSV 86_ SKGKI 91_ FNEMQ 96_ RLINE 101_ DPGSW 106_ LNAIS 111_ IWKNL 116_ LELDA 121_ KKEKL 126_ SQRDD 131_ NQLKR 136_ KVGEN 141_ EIIAK 146_ KLKIE 151_ QMQKI 156_ EENRD 161_ CQLEK 166_ QIKEE 171_ TLEQR 176_ DFTTK 181_ SEKFQ 186_ EEEFQ 191_ NDIEK 196_ AIDTH 201_ NQNDL 206_ TFRVS 211_ CRCSG 216_ TIGKA 221_ FTAQE 226_ VGKVI 231_ GIAIM 236_ KHFGW 241_ KADLR 246_ NPQLE 251_ IFIHL 256_ NDIYS 261_ VVGIP 266_ VFRVS 271_ LASRA 276_ YIKTA 281_ GLRST 286_ IAWAM 291_ ASLAD 296_ IKAGA 301_ FVLDP 306_ MCGLG 311_ TILLE 316_ AAKEW 321_ PDVYY 326_ VGADV 331_ SDSQL 336_ LGTWD 341_ NLKAA 346_ GLEDK 351_ IELLK 356_ ISVIE 361_ LPLPS 366_ ESVDI 371_ IISDI 376_ PFGKK 381_ FKLGK 386_ DIKSI 391_ LQEME 396_ RVLHV 401_ GGTIV 406_ LLLSE 411_ DHHRR 416_ LTDCK 421_ ESNIP 426_ FNSKD 431_ SHTDE 436_ PGIKK 441_ CLNPE 446_ EKTGA 451_ FKTAS 456_ TSFEA 461_ SNHKF 466_ LDRMS 471_ PFGSL 476_ VPVEC 481_ YKVSL 486_ GKTDA 491_ FICKY 496_KKSHS
1: Catalytic subunit of the THUMPD2-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotides, most probably at position 72 (m2G72), in the U6snRNA of the major spliceosome (PubMed:37283053). This modification in the U6 snRNA affects the constitutive splicing efficiency of introns that have suboptimal splice sites and can impact final mRNA levels (PubMed:37283053)