Gene name: RAMAC

Uniprot entry:

Q9BTL3

Protein names:

RNA guanine-N7 methyltransferase activating subunit (Protein FAM103A1) (RNA guanine-7 methyltransferase activating subunit) (RNMT-activating mRNA cap methyltransferase subunit) (RNMT-activating mini protein) (RAM)

Protein sequence:

1_MTDTA 6_ EAVPK 11_ FEEMF 16_ ASRFT 21_ ENDKE 26_ YQEYL 31_ KRPPE 36_ SPPIV 41_ EEWNS 46_ RAGGN 51_ QRNRG 56_ NRLQD 61_ NRQFR 66_ GRDNR 71_ WGWPS 76_ DNRSN 81_ QWHGR 86_ SWGNN 91_ YPQHR 96_ QEPYY 101_ PQQYG 106_ HYGYN 111_QRPPY

Protein annotations

Protein functions:

1: Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:22099306, PubMed:27422871). Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT (PubMed:27422871). Regulates RNMT expression by a post-transcriptional stabilizing mechanism (PubMed:22099306). Binds RNA (PubMed:22099306)