Ubiquitin-related modifier 1
1_MAAPL 6_ SVEVE 11_ FGGGA 16_ ELLFD 21_ GIKKH 26_ RVTLP 31_ GQEEP 36_ WDIRN 41_ LLIWI 46_ KKNLL 51_ KERPE 56_ LFIQG 61_ DSVRP 66_ GILVL 71_ INDAD 76_ WELLG 81_ ELDYQ 86_ LQDQD 91_ SVLFI 96_STLHG
1: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates