Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP-like protein) (LANP-L)
1_MEMKK 6_ KINLE 11_ LRNRS 16_ PEEVT 21_ ELVLD 26_ NCLCV 31_ NGEIE 36_ GLNDT 41_ FKELE 46_ FLSMA 51_ NVELS 56_ SLARL 61_ PSLNK 66_ LRKLE 71_ LSDNI 76_ ISGGL 81_ EVLAE 86_ KCPNL 91_ TYLNL 96_ SGNKI 101_ KDLST 106_ VEALQ 111_ NLKNL 116_ KSLDL 121_ FNCEI 126_ TNLED 131_ YRESI 136_ FELLQ 141_ QITYL 146_ DGFDQ 151_ EDNEA 156_ PDSEE 161_ EDDED 166_ GDEDD 171_ EEEEE 176_ NEAGP 181_ PEGYE 186_ EEEEE 191_ EEEED 196_ EDEDE 201_ DEDEA 206_ GSELG 211_ EGEEE 216_ VGLSY 221_ LMKEE 226_ IQDEE 231_ DDDDY 236_ VEEGE 241_ EEEEE 246_ EEGGL 251_ RGEKR 256_ KRDAE 261_DDGEE
1: Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis