Mediator of RNA polymerase II transcription subunit 10 (Mediator complex subunit 10) (Transformation-related gene 17 protein) (TRG-17) (Transformation-related gene 20 protein) (TRG-20)
1_MAEKF 6_ DHLEE 11_ HLEKF 16_ VENIR 21_ QLGII 26_ VSDFQ 31_ PSSQA 36_ GLNQK 41_ LNFIV 46_ TGLQD 51_ IDKCR 56_ QQLHD 61_ ITVPL 66_ EVFEY 71_ IDQGR 76_ NPQLY 81_ TKECL 86_ ERALA 91_ KNEQV 96_ KGKID 101_ TMKKF 106_ KSLLI 111_ QELSK 116_ VFPED 121_ MAKYR 126_SIRGE
1: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors