Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha)
1_MDETS 6_ PLVSP 11_ ERAQP 16_ PDYTF 21_ PSGSG 26_ AHFPQ 31_ VPGGA 36_ VRVAA 41_ AAGSG 46_ PSPPG 51_ SPGHD 56_ RERQP 61_ LLDRA 66_ RGAAA 71_ QGQTQ 76_ TVAAQ 81_ AQALA 86_ AQAAA 91_ AAHAA 96_ QAHRE 101_ RNEFP 106_ EDPEF 111_ EAVVR 116_ QAELA 121_ IERCI 126_ FPERI 131_ YQGSS 136_ GSYFV 141_ KDPQG 146_ RIIAV 151_ FKPKN 156_ EEPYG 161_ HLNPK 166_ WTKWL 171_ QKLCC 176_ PCCFG 181_ RDCLV 186_ LNQGY 191_ LSEAG 196_ ASLVD 201_ QKLEL 206_ NIVPR 211_ TKVVY 216_ LASET 221_ FNYSA 226_ IDRVK 231_ SRGKR 236_ LALEK 241_ VPKVG 246_ QRFNR 251_ IGLPP 256_ KVGSF 261_ QLFVE 266_ GYKDA 271_ DYWLR 276_ RFEAE 281_ PLPEN 286_ TNRQL 291_ LLQFE 296_ RLVVL 301_ DYIIR 306_ NTDRG 311_ NDNWL 316_ IKYDC 321_ PMDSS 326_ SSRDT 331_ DWVVV 336_ KEPVI 341_ KVAAI 346_ DNGLA 351_ FPLKH 356_ PDSWR 361_ AYPFY 366_ WAWLP 371_ QAKVP 376_ FSQEI 381_ KDLIL 386_ PKISD 391_ PNFVK 396_ DLEED 401_ LYELF 406_ KKDPG 411_ FDRGQ 416_ FHKQI 421_ AVMRG 426_ QILNL 431_ TQALK 436_ DNKSP 441_ LHLVQ 446_ MPPVI 451_ VETAR 456_ SHQRS 461_ SSESY 466_ TQSFQ 471_SRKPF
1: Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3)