Transmembrane protein 43 (Protein LUMA)
1_MAANY 6_ SSTST 11_ RREHV 16_ KVKTS 21_ SQPGF 26_ LERLS 31_ ETSGG 36_ MFVGL 41_ MAFLL 46_ SFYLI 51_ FTNEG 56_ RALKT 61_ ATSLA 66_ EGLSL 71_ VVSPD 76_ SIHSV 81_ APENE 86_ GRLVH 91_ IIGAL 96_ RTSKL 101_ LSDPN 106_ YGVHL 111_ PAVKL 116_ RRHVE 121_ MYQWV 126_ ETEES 131_ REYTE 136_ DGQVK 141_ KETRY 146_ SYNTE 151_ WRSEI 156_ INSKN 161_ FDREI 166_ GHKNP 171_ SAMAV 176_ ESFMA 181_ TAPFV 186_ QIGRF 191_ FLSSG 196_ LIDKV 201_ DNFKS 206_ LSLSK 211_ LEDPH 216_ VDIIR 221_ RGDFF 226_ YHSEN 231_ PKYPE 236_ VGDLR 241_ VSFSY 246_ AGLSG 251_ DDPDL 256_ GPAHV 261_ VTVIA 266_ RQRGD 271_ QLVPF 276_ STKSG 281_ DTLLL 286_ LHHGD 291_ FSAEE 296_ VFHRE 301_ LRSNS 306_ MKTWG 311_ LRAAG 316_ WMAMF 321_ MGLNL 326_ MTRIL 331_ YTLVD 336_ WFPVF 341_ RDLVN 346_ IGLKA 351_ FAFCV 356_ ATSLT 361_ LLTVA 366_ AGWLF 371_ YRPLW 376_ ALLIA 381_ GLALV 386_ PILVA 391_RTRVP
1: May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (PubMed:27991920). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing and speech discrimination (PubMed:34050020)