Diphthine methyltransferase (EC 3.1.1.97) (Diphthamide biosynthesis protein 7) (WD repeat-containing protein 85)
1_MMGCF 6_ ALQTV 11_ DTELT 16_ ADSVE 21_ WCPLQ 26_ GCRHL 31_ LACGT 36_ YQLRR 41_ PEDRP 46_ AGPQN 51_ KGGME 56_ VKEPQ 61_ VRLGR 66_ LFLYS 71_ FNDNN 76_ SIHPL 81_ VEVQR 86_ KDTSA 91_ ILDMK 96_ WCHIP 101_ VAGHA 106_ LLGLA 111_ DASGS 116_ IQLLR 121_ LVESE 126_ KSHVL 131_ EPLSS 136_ LALEE 141_ QCLAL 146_ SLDWS 151_ TGKTG 156_ RAGDQ 161_ PLKII 166_ SSDST 171_ GQLHL 176_ LMVNE 181_ TRPRL 186_ QKVAS 191_ WQAHQ 196_ FEAWI 201_ AAFNY 206_ WHPEI 211_ VYSGG 216_ DDGLL 221_ RGWDT 226_ RVPGK 231_ FLFTS 236_ KRHTM 241_ GVCSI 246_ QSSPH 251_ REHIL 256_ ATGSY 261_ DEHIL 266_ LWDTR 271_ NMKQP 276_ LADTP 281_ VQGGV 286_ WRIKW 291_ HPFHH 296_ HLLLA 301_ ACMHS 306_ GFKIL 311_ NCQKA 316_ MEERQ 321_ EATVL 326_ TSHTL 331_ PDSLV 336_ YGADW 341_ SWLLF 346_ RSLQR 351_ APSWS 356_ FPSNL 361_ GTKTA 366_ DLKGA 371_ SELPT 376_ PCHEC 381_ REDND 386_ GEGHA 391_ RPQSG 396_ MKPLT 401_ EGMRK 406_ NGTWL 411_ QATAA 416_ TTRDC 421_ GVNPE 426_ EADSA 431_ FSLLA 436_ TCSFY 441_ DHALH 446_LWEWE
1: Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta)