Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D)
1_MALSD 6_ EPAAG 11_ GPEEE 16_ AEDET 21_ LAFGA 26_ ALEAF 31_ GESAE 36_ TRALL 41_ GRLRE 46_ VHGGG 51_ AEREV 56_ ALERF 61_ RVIMD 66_ KYQEQ 71_ PHLLD 76_ PHLEW 81_ MMNLL 86_ LDIVQ 91_ DQTSP 96_ ASLVH 101_ LAFKF 106_ LYIIT 111_ KVRGY 116_ KTFLR 121_ LFPHE 126_ VADVE 131_ PVLDL 136_ VTIQN 141_ PKDHE 146_ AWETR 151_ YMLLL 156_ WLSVT 161_ CLIPF 166_ DFSRL 171_ DGNLL 176_ TQPGQ 181_ ARMSI 186_ MDRIL 191_ QIAES 196_ YLIVS 201_ DKARD 206_ AAAVL 211_ VSRFI 216_ TRPDV 221_ KQSKM 226_ AEFLD 231_ WSLCN 236_ LARSS 241_ FQTMQ 246_ GVITM 251_ DGTLQ 256_ ALAQI 261_ FKHGK 266_ REDCL 271_ PYAAT 276_ VLRCL 281_ DGCRL 286_ PESNQ 291_ TLLRK 296_ LGVKL 301_ VQRLG 306_ LTFLK 311_ PKVAA 316_ WRYQR 321_ GCRSL 326_ AANLQ 331_ LLTQG 336_ QSEQK 341_ PLILT 346_ EDDDE 351_ DDDVP 356_ EGVER 361_ VIEQL 366_ LVGLK 371_ DKDTV 376_ VRWSA 381_ AKGIG 386_ RMAGR 391_ LPRAL 396_ ADDVV 401_ GSVLD 406_ CFSFQ 411_ ETDKA 416_ WHGGC 421_ LALAE 426_ LGRRG 431_ LLLPS 436_ RLVDV 441_ VAVIL 446_ KALTY 451_ DEKRG 456_ ACSVG 461_ TNVRD 466_ AACYV 471_ CWAFA 476_ RAYEP 481_ QELKP 486_ FVTAI 491_ SSALV 496_ IAAVF 501_ DRDIN 506_ CRRAA 511_ SAAFQ 516_ ENVGR 521_ QGTFP 526_ HGIDI 531_ LTTAD 536_ YFAVG 541_ NRSNC 546_ FLVIS 551_ VFIAG 556_ FPEYT 561_ QPMID 566_ HLVTM 571_ KISHW 576_ DGVIR 581_ ELAAR 586_ ALHNL 591_ AQQAP 596_ EFSAT 601_ QVFPR 606_ LLSMT 611_ LSPDL 616_ HMRHG 621_ SILAC 626_ AEVAY 631_ ALYKL 636_ AAQEN 641_ RPVTD 646_ HLDEQ 651_ AVQGL 656_ KQIHQ 661_ QLYDR 666_ QLYRG 671_ LGGQL 676_ MRQAV 681_ CVLIE 686_ KLSLS 691_ KMPFR 696_ GDTVI 701_ DGWQW 706_ LINDT 711_ LRHLH 716_ LISSH 721_ SRQQM 726_ KDAAV 731_ SALAA 736_ LCSEY 741_ YMKEP 746_ GEADP 751_ AIQEE 756_ LITQY 761_ LAELR 766_ NPEEM 771_ TRCGF 776_ SLALG 781_ ALPGF 786_ LLKGR 791_ LQQVL 796_ TGLRA 801_ VTHTS 806_ PEDVS 811_ FAESR 816_ RDGLK 821_ AIARI 826_ CQTVG 831_ VKAGA 836_ PDEAV 841_ CGENV 846_ SQIYC 851_ ALLGC 856_ MDDYT 861_ TDSRG 866_ DVGTW 871_ VRKAA 876_ MTSLM 881_ DLTLL 886_ LARSQ 891_ PELIE 896_ AHTCE 901_ RIMCC 906_ VAQQA 911_ SEKID 916_ RFRAH 921_ AASVF 926_ LTLLH 931_ FDSPP 936_ IPHVP 941_ HRGEL 946_ EKLFP 951_ RSDVA 956_ SVNWS 961_ APSQA 966_ FPRIT 971_ QLLGL 976_ PTYRY 981_ HVLLG 986_ LVVSL 991_ GGLTE 996_ STIRH 1001_ STQSL 1006_ FEYMK 1011_ GIQSD 1016_ PQALG 1021_ SFSGT 1026_ LLQIF 1031_ EDNLL 1036_ NERVS 1041_ VPLLK 1046_ TLDHV 1051_ LTHGC 1056_ FDIFT 1061_ TEEDH 1066_ PFAVK 1071_ LLALC 1076_ KKEIK 1081_ NSKDI 1086_ QKLLS 1091_ GIAVF 1096_ CEMVQ 1101_ FPGDV 1106_ RRQAL 1111_ LQLCL 1116_ LLCHR 1121_ FPLIR 1126_ KTTAS 1131_ QVYET 1136_ LLTYS 1141_ DVVGA 1146_ DVLDE 1151_ VVTVL 1156_ SDTAW 1161_ DAELA 1166_ VVREQ 1171_ RNRLC 1176_ DLLGV 1181_ PRPQL 1186_VPQPG
1: Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (PubMed:10722852, PubMed:10831612, PubMed:11847227, PubMed:20740604, PubMed:27666370, PubMed:28158450). Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis (PubMed:27666370). Involved in neuron morphogenesis (PubMed:27666374)