Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase) (CR) (NADPH-dependent retinol dehydrogenase/reductase) (NRDR) (humNRDR) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) (SCAD-SRL) (Short chain dehydrogenase/reductase family 25C member 2) (Protein SDR25C2) (Short-chain dehydrogenase/reductase family member 4)
1_MHKAG 6_ LLGLC 11_ ARAWN 16_ SVRMA 21_ SSGMT 26_ RRDPL 31_ ANKVA 36_ LVTAS 41_ TDGIG 46_ FAIAR 51_ RLAQD 56_ GAHVV 61_ VSSRK 66_ QQNVD 71_ QAVAT 76_ LQGEG 81_ LSVTG 86_ TVCHV 91_ GKAED 96_ RERLV 101_ ATAVK 106_ LHGGI 111_ DILVS 116_ NAAVN 121_ PFFGS 126_ IMDVT 131_ EEVWD 136_ KTLDI 141_ NVKAP 146_ ALMTK 151_ AVVPE 156_ MEKRG 161_ GGSVV 166_ IVSSI 171_ AAFSP 176_ SPGFS 181_ PYNVS 186_ KTALL 191_ GLTKT 196_ LAIEL 201_ APRNI 206_ RVNCL 211_ APGLI 216_ KTSFS 221_ RMLWM 226_ DKEKE 231_ ESMKE 236_ TLRIR 241_ RLGEP 246_ EDCAG 251_ IVSFL 256_ CSEDA 261_ SYITG 266_ ETVVV 271_GGGTP
1: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones (PubMed:18571493, PubMed:19056333). Reduces 3-ketosteroids and benzil into 3beta-hydroxysteroids and R-benzoin, respectively, in contrast to the stereoselectivity of non-primate DHRS4s which produce 3alpha-hydroxysteroids and S-benzoin (PubMed:19056333). Diplays low activity toward all-trans-retinal and no activity toward 9-cis-retinal as compared to non-primate mammals (PubMed:18571493, PubMed:19056333). In the reverse reaction, catalyze the NAD-dependent oxidation of 3beta-hydroxysteroids and alcohol, but with much lower efficiency (PubMed:18571493, PubMed:19056333). Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds (PubMed:18571493, PubMed:19056333)
2: No detected catalytic activity in vitro, possibly due to the lack of catalytic site
3: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds. Has a higher catalytic activity for xenobiotic alpha-dicarbonyl compounds, sucha as benzil, than isoform 1 and is involved in benzil detoxification