Deoxyhypusine hydroxylase (hDOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase) (HEAT-like repeat-containing protein 1)
1_MVTEQ 6_ EVDAI 11_ GQTLV 16_ DPKQP 21_ LQARF 26_ RALFT 31_ LRGLG 36_ GPGAI 41_ AWISQ 46_ AFDDD 51_ SALLK 56_ HELAY 61_ CLGQM 66_ QDARA 71_ IPMLV 76_ DVLQD 81_ TRQEP 86_ MVRHE 91_ AGEAL 96_ GAIGD 101_ PEVLE 106_ ILKQY 111_ SSDPV 116_ IEVAE 121_ TCQLA 126_ VRRLE 131_ WLQQH 136_ GGEPA 141_ AGPYL 146_ SVDPA 151_ PPAEE 156_ RDVGR 161_ LREAL 166_ LDESR 171_ PLFER 176_ YRAMF 181_ ALRNA 186_ GGEEA 191_ ALALA 196_ EGLHC 201_ GSALF 206_ RHEVG 211_ YVLGQ 216_ LQHEA 221_ AVPQL 226_ AAALA 231_ RCTEN 236_ PMVRH 241_ ECAEA 246_ LGAIA 251_ RPACL 256_ AALQA 261_ HADDP 266_ ERVVR 271_ ESCEV 276_ ALDMY 281_ EHETG 286_ RAFQY 291_ ADGLE 296_QLRGA
1: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine (PubMed:16371467, PubMed:16533814, PubMed:19706422). Hypusination is unique to mature eIF-5A factor and is essential for its function (By similarity)