Mediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18) (p28b)
1_MEAPP 6_ VTMMP 11_ VTGGT 16_ INMME 21_ YLLQG 26_ SVLDH 31_ SLESL 36_ IHRLR 41_ GLCDN 46_ MEPET 51_ FLDHE 56_ MVFLL 61_ KGQQA 66_ SPFVL 71_ RARRS 76_ MDRAG 81_ APWHL 86_ RYLGQ 91_ PEMGD 96_ KNRHA 101_ LVRNC 106_ VDIAT 111_ SENLT 116_ DFLME 121_ MGFRM 126_ DHEFV 131_ AKGHL 136_ FRKGI 141_ MKIMV 146_ YKIFR 151_ ILVPG 156_ NTDST 161_ EALSL 166_ SYLVE 171_ LSVVA 176_ PAGQD 181_ MVSDD 186_ MKNFA 191_ EQLKP 196_ LVHLE 201_KIDPK
1: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors