Protein crumbs homolog 3
1_MANPG 6_ LGLLL 11_ ALGLP 16_ FLLAR 21_ WGRAW 26_ GQIQT 31_ TSANE 36_ NSTVL 41_ PSSTS 46_ SSSDG 51_ NLRPE 56_ AITAI 61_ IVVFS 66_ LLAAL 71_ LLAVG 76_ LALLV 81_ RKLRE 86_ KRQTE 91_ GTYRP 96_ SSEEQ 101_ VGARV 106_ PPTPN 111_LKLPP
1: Involved in the establishment of cell polarity in mammalian epithelial cells (PubMed:12771187, PubMed:14718572, PubMed:23439680). Regulates the morphogenesis of tight junctions (PubMed:12771187, PubMed:14718572). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity)