Protein PAXX (Paralog of XRCC4 and XLF) (XRCC4-like small protein)
1_MDPLS 6_ PPLCT 11_ LPPGP 16_ EPPRF 21_ VCYCE 26_ GEESG 31_ EGDRG 36_ GFNLY 41_ VTDAA 46_ ELWST 51_ CFTPD 56_ SLAAL 61_ KARFG 66_ LSAAE 71_ DITPR 76_ FRAAC 81_ EQQAV 86_ ALTLQ 91_ EDRAS 96_ LTLSG 101_ GPSAL 106_ AFDLS 111_ KVPGP 116_ EAAPR 121_ LRALT 126_ LGLAK 131_ RVWSL 136_ ERRLA 141_ AAEET 146_ AVSPR 151_ KSPRP 156_ AGPQL 161_ FLPDP 166_ DPQRG 171_ GPGPG 176_ VRRRC 181_ PGESL 186_ INPGF 191_ KSKKP 196_AGGVD
1: Non-essential DNA repair protein involved in DNA non-homologous end joining (NHEJ); participates in double-strand break (DSB) repair and V(D)J recombination (PubMed:25574025, PubMed:25670504, PubMed:25941166, PubMed:27705800). May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery (PubMed:25574025, PubMed:25670504, PubMed:25941166). Involved in NHEJ by promoting the ligation of blunt-ended DNA ends (PubMed:27703001). Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (PubMed:25670504, PubMed:30250067). Constitutes a non-essential component of classical NHEJ: has a complementary but distinct function with NHEJ1/XLF in DNA repair (PubMed:27705800). Able to restrict infection by herpesvirus 1 (HSV-1) via an unknown mechanism (PubMed:29144403)