DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (DNA-directed RNA polymerase III subunit C) (RNA polymerase III 62 kDa subunit) (RPC62)
1_MTQAE 6_ IKLCS 11_ LLLQE 16_ HFGEI 21_ VEKIG 26_ VHLIR 31_ TGSQP 36_ LRVIA 41_ HDTGT 46_ SLDQV 51_ KKALC 56_ VLVQH 61_ NLVSY 66_ QVHKR 71_ GVVEY 76_ EAQCS 81_ RVLRM 86_ LRYPR 91_ YIYTT 96_ KTLYS 101_ DTGEL 106_ IVEEL 111_ LLNGK 116_ LTMSA 121_ VVKKV 126_ ADRLT 131_ ETMED 136_ GKTMD 141_ YAEVS 146_ NTFVR 151_ LADTH 156_ FVQRC 161_ PSVPT 166_ TENSD 171_ PGPPP 176_ PAPTL 181_ VINEK 186_ DMYLV 191_ PKLSL 196_ IGKGK 201_ RRRSS 206_ DEDAA 211_ GEPKA 216_ KRPKY 221_ TTDNK 226_ EPIPD 231_ DGIYW 236_ QANLD 241_ RFHQH 246_ FRDQA 251_ IVSAV 256_ ANRMD 261_ QTSSE 266_ IVRTM 271_ LRMSE 276_ ITTSS 281_ SAPFT 286_ QPLSS 291_ NEIFR 296_ SLPVG 301_ YNISK 306_ QVLDQ 311_ YLTLL 316_ ADDPL 321_ EFVGK 326_ SGDSG 331_ GGMYV 336_ INLHK 341_ ALASL 346_ ATATL 351_ ESVVQ 356_ ERFGS 361_ RCARI 366_ FRLVL 371_ QKKHI 376_ EQKQV 381_ EDFAM 386_ IPAKE 391_ AKDML 396_ YKMLS 401_ ENFMS 406_ LQEIP 411_ KTPDH 416_ APSRT 421_ FYLYT 426_ VNILS 431_ AARML 436_ LHRCY 441_ KSIAN 446_ LIERR 451_ QFETK 456_ ENKRL 461_ LEKSQ 466_ RVEAI 471_ IASMQ 476_ ATGAE 481_ EAQLQ 486_ EIEEM 491_ ITAPE 496_ RQQLE 501_ TLKRN 506_ VNKLD 511_ ASEIQ 516_ VDETI 521_ FLLES 526_YIECT
1: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:33558766, PubMed:34675218, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (PubMed:20413673, PubMed:33558764, PubMed:33558766, PubMed:35637192). Part of POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer, coordinates the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state (PubMed:33558764, PubMed:33558766). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner (PubMed:21358628)