Programmed cell death protein 10 (Cerebral cavernous malformations 3 protein) (TF-1 cell apoptosis-related protein 15)
1_MRMTM 6_ EEMKN 11_ EAETT 16_ SMVSM 21_ PLYAV 26_ MYPVF 31_ NELER 36_ VNLSA 41_ AQTLR 46_ AAFIK 51_ AEKEN 56_ PGLTQ 61_ DIIMK 66_ ILEKK 71_ SVEVN 76_ FTESL 81_ LRMAA 86_ DDVEE 91_ YMIER 96_ PEPEF 101_ QDLNE 106_ KARAL 111_ KQILS 116_ KIPDE 121_ INDRV 126_ RFLQT 131_ IKDIA 136_ SAIKE 141_ LLDTV 146_ NNVFK 151_ KYQYQ 156_ NRRAL 161_ EHQKK 166_ EFVKY 171_ SKSFS 176_ DTLKT 181_ YFKDG 186_ KAINV 191_ FVSAN 196_ RLIHQ 201_ TNLIL 206_QTFKT
1: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity)