Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1)
1_MSDIG 6_ DWFRS 11_ IPAIT 16_ RYWFA 21_ ATVAV 26_ PLVGK 31_ LGLIS 36_ PAYLF 41_ LWPEA 46_ FLYRF 51_ QIWRP 56_ ITATF 61_ YFPVG 66_ PGTGF 71_ LYLVN 76_ LYFLY 81_ QYSTR 86_ LETGA 91_ FDGRP 96_ ADYLF 101_ MLLFN 106_ WICIV 111_ ITGLA 116_ MDMQL 121_ LMIPL 126_ IMSVL 131_ YVWAQ 136_ LNRDM 141_ IVSFW 146_ FGTRF 151_ KACYL 156_ PWVIL 161_ GFNYI 166_ IGGSV 171_ INELI 176_ GNLVG 181_ HLYFF 186_ LMFRY 191_ PMDLG 196_ GRNFL 201_ STPQF 206_ LYRWL 211_ PSRRG 216_ GVSGF 221_ GVPPA 226_ SMRRA 231_ ADQNG 236_ GGGRH 241_ NWGQG 246_FRLGD
1: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins (PubMed:15215856, PubMed:33658201). Forms homotetramers which encircle a large channel traversing the endoplasmic reticulum (ER) membrane (PubMed:33658201). This allows the retrotranslocation of misfolded proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome (PubMed:33658201). The channel has a lateral gate within the membrane which provides direct access to membrane proteins with no need to reenter the ER lumen first (PubMed:33658201). May mediate the interaction between VCP and the misfolded protein (PubMed:15215856). Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333)
2: (Microbial infection) In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein